Brief and complete title
No more than 20 words; no more than 150 characters in total, including spaces. Avoid using jargon, uncommon abbreviations, and punctuation. Identify the report as a Meta-Analysis.

Forename Surname1, Forename Surname1,2, Forename Surname1*
1Dept/Program/Center, Institution, City, State, Postcode, Country
2Dept/Program/Center, Institution, City, State, Postcode, Country

Correspondence: Corresponding Author Name, Dept/Program/Center, Institution, City, State, Postcode, Country; email@email.com
ORCID of each author (Optional, but strongly encouraged).

Abstract
Structured abstract with four sections. No more than 300 words. No footnotes and references.

• Background: Provide an explicit statement of the main objective(s) or question(s) the review addresses.
• Methods: Briefly describe the methods used to present and synthesize results. Specify the inclusion criteria for the review and the information sources (e.g. databases, registers) used to identify studies.
• Results: Present results for main outcomes, preferably indicating the number of included studies and participants for each. A meta-analysis should report the summary estimate and confidence/credible interval. If comparing groups, indicate the direction of the effect (i.e. which group is favored).
• Discussion: Provide a general interpretation of the results and important implications.

Keywords
Three to eight keywords.
Keyword 1, Keyword 2, Keyword 3

Introduction
The introduction should briefly describe the rationale for the review in the context of existing knowledge and provide an explicit statement of the objective(s) or question(s) the review addresses. The current state of the research field should be reviewed carefully and key publications cited if necessary. Subheadings and conclusions are not permitted in this part.

Materials and Methods
This section should provide sufficient details of the inclusion and exclusion criteria for the review and how studies were grouped for the syntheses. Specify all databases, registers, websites, organizations, reference lists, and other sources searched or consulted to identify studies. Any methods used to synthesize results should be described, and a rationale for the choice(s) should be provided. A meta-analysis should also describe the model(s), method(s) to identify the presence and extent of statistical heterogeneity, and software package(s) used.

• The Trial Registration Number: CRD12345678910; NCT12345678 (if applicable).

Results
This section should describe the results of the search and selection process, from the number of records identified in the search to the number of studies included in the review, ideally using a flow diagram. It should present the results of all statistical syntheses conducted. A meta-analysis should present each summary estimate and its precision (e.g. confidence/credible interval) and measures of statistical heterogeneity. If comparing groups, describe the direction of the effect.

• Subsections: Results can be divided into subheadings, with tables, figures, photographs, and other appropriate forms used and numbered in order.

Advice on Tables and Figures

• All tables and figures should be placed after the paragraph where they first appear and should be cited in numeric order in the main text.

Tables
All tables should be cited in a consecutive order as Table 1, Table 2, etc.; each table must have a descriptive caption above the table; when numerical measurements are given, the units should be included in the column heading; vertical rules should not be used. Tables may have footnotes according to the actual need, with reasonable explanations about footnotes.
Example:
Table 1. This is the table caption

Structure	Time (h)	Temperature (°C)
entry 1	data※	data
entry 2	data	data
※Please explain what “※” stands for

Figures
All figures should be cited in a consecutive order as Figure 1, Figure 2, etc.; each figure must have an accompanying caption under the figure that includes a title and, preferably, a brief description. All labels (symbols, arrows, numbers, or letters) and non-standard abbreviations should be explained in the figure caption. All original figure files should be uploaded when manuscripts are submitted.
Example:
Figure 1. Three graphics of shape. A: Pentacle; B: arrow; C: pentagon

Discussion
This section should provide a general interpretation of the results in the context of other evidence and describe any limitations of the evidence included in the review. The implications of the results for practice, policy, and future research can also be highlighted.

Abbreviations
Please explain all the abbreviations included in the manuscript in alphabetical order. For example,
FBS: fetal bovine serum
HGF: hepatocyte growth factor

Declarations

• Acknowledgments (Optional): Authors may acknowledge those individuals who provided help during the research and preparation of the manuscript. This section is not added if the author does not have anyone to acknowledge.
• Author Contributions: Describe the contributions of each author using CRediT Taxonomy.
• Conflicts of Interest: Authors must reveal any possible conflicts of interest. If there are no conflicts of interest, state, “The authors declare that they have no conflicts of interest.”
• Ethical Approval: Specify approval details if applicable, otherwise state, “Not applicable.”
• Consent to Participate: Specify if informed consent was obtained, otherwise state, “Not applicable.”
• Consent to Publication: Specify if consent for publication was obtained, otherwise state, “Not applicable.”
• Availability of Data and Materials: State where data can be found or declare if it’s not applicable.
• Funding: All sources of funding should be declared, otherwise state, “Not applicable.”
• Copyright: © The Author(s) Year.

References
References should be numbered in order of appearance and presented as numerals in square brackets in the article. Follow the reference style indicated in the journal's guidelines. Example:

1. Rose ME, Huerbin MB, Melick J, et al. Regulation of interstitial excitatory amino acid concentrations after cortical contusion injury. Brain Res. 2002;935:40-6.